jm's Adventure with Multiple Myeloma: Pomalidomide (Pomalyst) Update For Relapse After 7 Doses - March 12 2013

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Wednesday, March 13, 2013

Pomalidomide (Pomalyst) Update For Relapse After 7 Doses - March 12 2013

Absolutely NO sleep last night - My gastrointestinal track has just STOPPED all of a sudden and I suffered all night. Took Senna-S and Phillips Tab - hope things start up again SOON.

Took half of my weekly 40 mg Dex for the day with breakfast (20 mg). Will take the second half with dinner since I take my Pomalyst at bedtime.

My GI tract started back up, but, I am still distended in my abdomen.

Update after first 7 days of pomalidomide (Pomalyst) 4 mg. Drove to Lost Rivers Medical Center in Arco, Idaho (30 miles each way) and had my blood drawn to see how my bone marrow is reacting to the new Pomalyst. They had not received my blood draw order from St. Luke's Hospital in Twin Falls, Idaho and I had to call them to get the order which came quickly, but lacked the LDH which should have been drawn - oh well.

My labs are not much different than before I started the Pomalyst 4 mg. My white blood cell count (WBC)  is low at 2.2 (norms 4.5-11 and reflects your ability to fight infection); ANC (absolute neurtrophil count  is low at 1.36 (norms 1.9-8.8 and reflects your immune system quality and whether you can be in public with or without a mask); hemoglobin low at 9.2 (norms 12-16 and reflects your oxygen carrying capacity or energy level) and platelets low at 97 (norms 140-440 and reflects your ability to clot your blood). I hope my platelets hang in there throughout the Cycle 1 (21/28 days).
My kidney function tests via my blood continue slightly abnormal. My creatinine is slightly high at 1.10 (norms 0.52-1.04); BUN is normal at 14.4 (norms 7-17); and GFR is abnormally low at 53 (norms > 60). My liver function tests are back to normal since I stopped plain Tylenol.

Drove back to Mackay and pretty much slept all day on the sofa...had to make up for that sleepless night.  Had a little gastritis, but nothing too bad.

The St. Luke's Hospital MSTI (Mountain States Tumor Institute) Pharmacist from Boise called today to ask me about any side effects that I've had from the Pomalyst. They have to report side effects to the manufacturer, Celgene, and they will be calling me each week. I explained that the only side effects that I could attribute to Pomalyst were:
  • burning scalp (improving)
  • creepy legs (had before I started Pomalyst, but seems worse at night – taking 1/4th to ½ tabs of plain Oxy which helps. Trying to balance dosage so I don’t feel hung over during the day)
  • increased neuropathy of left leg especially from knee to groin – was about a 2 (1-10 scale) prior to Pomalyst and now 4. I am attributing my left hip pain to neuropathy now since all of my tests (plain x-rays and MRI were normal).
  • tired, especially after taking
  • constipation (I forgot to tell her this, I will next week)
My neighbors this morning.


  1. I am so sorry you are suffering with this new treatment. Intending you are getting balanced out and feeling better soon.

  2. Sandy, other than the constipation, I am not suffering - you can save that for later - IF NEEDED! It's really nice here in Mackay, Idaho to - 51 degrees, sunny, and no wind - Kemmer and I headed out to enjoy a walk. jm

  3. Stay strong, Rudi! This may be a tough time for you, but all these trials are just temporary. Try consuming fresh fruits everyday! You may be surprised just how effective these fresh foods are to your body. The fact that you can take them in fluid means they are good for you. Only, they do not need to go through your IV’s. Less hassle, right? And continue with your therapies for faster healing.

    Cami Hood

  4. Wishing you only great results

  5. Thanks everyone for your positive thoughts. jm (Judy Malkiewicz, Mackay, Idaho). I have no idea how this computer decides which identity I'll have.... :)

  6. i am in pain all the time i think its from the pmalyst, this is my 3rd week on it the first week my numberss were better then they ever were so that is a good sign.

  7. Hi Joe, I'm sorry you have so much pain and hope they can help you with some relief. Terrific that your counts are improving. I've had to hold pomalyst for now until my platelet count recovers. jm