jm's Adventure with Multiple Myeloma: 2nd ASCT - Day 145

Wednesday, October 10, 2012

2nd ASCT - Day 145 - October 10 2012

Well, 1/2 Imodium tablet and Velcade subcutaneously on Tuesday (10/9/12) has complete shut down my GI tract. So, I'll probably have to take a Senna-S and Phillips Tab tonight to get going again. I am so sensitive to Imodium and I am SO GLAD that I remembered to take only 1/2 on Tuesday.

I have had more energy today and got a lot of house tasks started like covering my crawl space opening for winter. Took Bart (2006 Honda) in for a rock chip repair that I got yesterday on my Twin Falls trip. Just needed to drive 44 miles round trip to get it done!

Didn't need a nap this afternoon. Got a lot of scanning done for the historical society and my own genealogy.

My left foot and leg neuropathy seems improved since I started taking the Ursolic Acid yesterday. That is the only thing different in my daily medications - so, it must be that. But, I'm only taking it for 3 days around my Velcade subcutaneous injection as Ursolic Acid potentiate the action of Velcade and lower your blood counts.

Curascript sent my new 14 days of Zolinza today via FedEx. I hope I don't have to take it anymore and can sent it back.

2 comments:

SandyOctober 12, 2012 at 1:18 PM
I don't understand why you won't try the sublingual Vit B for the neuropathy since it will not lower your blood counts...??? And it will help with stress - like driving 44 miles round trip to get your car worked on...LOL!
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Judy MalkiewiczOctober 12, 2012 at 1:21 PM
Sandy, I forgot to post that I am taking sublingual Vit B already. Thanks for your concern. jm
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My Muliple Myeloma History

At the age of 60, I was diagnosed with High Risk Monocolonal IgG Kappa Multiple Myeloma on May 24, 2011 after a routine physical exam blood test revealing anemia. I had 80 percent neoplastic plasma cells with cytogenetic 4:14 and deletion of 13 changes in my bone marrow and a M-Spike of 3.0. I started induction chemotherapy of IV Velcade, IV Dexamethasone, and PO Revlimid on June 13 2011 and did 3 ½ cycles. I was admitted to the University of Colorado Hospital (UCH) for a four day course of VDT-PACE (Velcade IV, Dexamethasone IV, Thalidomide P, Cisplatin (P) IV, Adriamycin IV, Cytoxan IV, and Etopside IV) as my cytogenetic profile changed to include 1q21. Harvested my stem cells and had an autologous stem cell transplant on September 13 2011. My bone marrow 50 days after transplant was deemed in Stringent Complete Remission on November 2 2011 with an M-Spike of 0.1. As a result of my Trifusion Hickman Catheter, I developed blood clots in my heart. The Trifusion Catheter and Bard Power Port were removed and I continue on daily blood thinner injections of Fragmin. Maintenance chemotherapy of Velcade/Dex/Revlimid and Zometa started December 1 2011. After 7 long months away from home in Mackay, Idaho for induction chemotherapy, autologous stem cell transplant, and beginning maintenance chemotherapy at the University of Colorado Hospital, I was able to return home to continue maintenance chemo.

My m-spike increased to 0.59 on 27 Feb 2012 - back to UCH in Colorado.

Relapse confirmed with Bone Marrow Biopsy with 50% plasma cells on 9 Mar 2012. Admitted UCH for Cycle 1 VDT-PACE 16-20 March 2012 with PICC Line Placement. Re-admitted for Cycle 2 VD-PACE 13-17 April 2012.

Bone Marrow Biopsy on 3 May 2012 reveals 1 percent plasma cells with 1q21 (3.5 percent) and 4:14 (0.3 percent) cytogenetic changes. Admitted UCH for 2nd Autologous Stem Cell Transplant 11 May 2012 for BEAM Chemotherapy. Melphalan given 16 May 2012 and my stem cells were given to me on 18 May 2012. Returned home to Idaho on Day 28. 2nd ASCT Followup Day 55 on 12 July 2012 showed M-Spike of less than 0.1 and bone marrow biopsy shows persistent abnormal cytogenetics 4:14 and 1q21. Started continuing chemotherapy of Velcade and Dex again on 8-20 Aug 2012. Vorinostat (Zolinza) 400 mg 14 days on 14 days off added 4 Sept 2012. Did 2 cycles of Zolinza and all it did for me is increase my creatinine. Bone Marrow Biopsy on 17 Oct 2012 confirmed relapse with 60 % plasma cells. Will start Carfilzomib/Dex (2x weekly for 3 weeks and 1 week off) and Revlimid 10 mg (21 days 0n) on 30 Oct 2012. After 2 cycles of carfilzomib/Dex/Revlimid had repeat Bone Marrow Biopsy on 20 Dec 2012 which revealed decrease in plasma cells to 40 %. Response was not as good as expected, so started 3rd cycle of carfilzomib/dex/revlimid with added cytoxan. Cytoxan caused my blood values to plummet and my 20 Feb 2013 bone marrow biopsy revealed 60 percent plasma cells - RELAPSE on top of RELAPSE. Started pomalidomide with 40 mg Dex on 5 March 2013. Blood values continue to be LOW.

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Wednesday, October 10, 2012

2nd ASCT - Day 145 - October 10 2012

2 comments:

My Muliple Myeloma History

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